BENEDORM MELATONIN 5MG 40SUBLINGUAL TABLETS

In stock
$51.67 USD
CONTAINT: 40 SUBLINGUAL TABLETS
LABORATORY: VALEANT
BRAND NAME: BENEDORM
ACTIVE INGREDIENT: MELATONIN 5MG
BENEDORM® is indicated as a sleep inducer and stabilizer in patients with early insomnia (difficulty falling asleep), intermediate insomnia (spontaneous awakenings during the night), late insomnia (difficulty maintaining or shortening sleep) and to correct circadian cycles of sleep and wakefulness in patients with early or delayed sleep phase syndromes and in patients who suffer schedule changes due to travel or work activity.
 
Melatonin is a hormone that acts through receptors distributed in the brain, which activate binding proteins and enzymes such as guanosine triphosphate, adenylate cyclase and phosphodiesterases at the intracellular level. Administered in the afternoon or evening, it achieves adequate sleep induction, reduces the latency period, increases the duration of sleep and its quality, and facilitates a comforting awakening.
 
BENEDORM® has shown varying degrees of effectiveness in sleep disorders, as well as jet lag syndrome. Clinical data and those obtained through research in sleep laboratories show that the improvement observed with the use of melatonin is attributed to the hypnotic effect, similar to that of benzodiazepines and without their adverse effects. With the regular use of BENEDORM® in patients with insomnia, a reduction in the latency period is obtained, as well as an increase in the duration and an improvement in the quality of sleep.
 
With sublingual administration, a more complete and faster absorption is facilitated, in addition to avoiding the extensive first-pass metabolism that occurs when administered orally, thereby achieving a faster effect and obtaining a greater quantity. of effective drug in the body, avoiding the great variability of interpatient bioavailability, which is observed with oral administration.
 
After sublingual administration, melatonin is rapidly and almost completely absorbed. When administered at night, maximum plasma concentrations are obtained 30 minutes after administration, the concentration varies from 2,240 to 16,808 pg/mL, with an X ± SD of 8,559 ± 5,920.58. Exogenously administered, it is distributed to most tissues with high concentrations in the ovaries and pineal gland. High concentrations have also been observed in saliva after oral doses. Melatonin is highly lipophilic and crosses the blood-brain barrier. With sublingual administration, first-pass metabolism is initially avoided, thereby delaying its hepatic metabolism to 6-hydroxymelatonin and N-acetylserotonin, inactive metabolites, which are excreted as glucuronide and sulfate conjugates. Most exogenous melatonin is excreted via the urinary route as 6-hydroxymelatonin sulfate (up to 85%). Only small amounts appear as unchanged hormone.
 
The elimination half-life (t½) after sublingual administration ranges from 7.7 to 27 minutes, unlike t½
observed after oral administration ranging from 30 to 50 minutes. Regarding the clearance observed after sublingual administration, the average data is 0.864 ± 0.978
mL/kg/min.
CONTAINT
40 SUBLINGUAL TABLETS
LABORATORY
VALEANT
BRAND NAME
BENEDORM
ACTIVE INGREDIENT
MELATONIN 5MG
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What are your shipping rates and policies?
At the moment we offer 1 shipping option:

Regular Airmail Delivery (15-24 business days)
 
Once your order has been shipped, we will send you an email to notify you that your product has left our facilities. From this point on, your product is only 15-24 business days.

Please note that orders are shipped on business days only (Monday through Friday, excluding holidays).

You can view our shipping rate and other information after selecting a particular product.

Do you ship internationally?
yes
 
In what currency is my purchase transaction received?
The currency used will be the US dollar.

How will my medication be packaged?
Your order will be properly packaged for your protection in transit to destination.

Where are the medications shipped from?
We ship from our office in Acapulco, Gro. Mexico

Where are the drugs you have to sell made?
Most of the drugs we offer are manufactured in Mexico, some are manufactured in countries such as Germany, England, France and others, all manufactured by large multinational laboratories legally established in Mexico.

What is the expiration date of the medications I receive?
We offer the guarantee that your product will have at least 10 months of use at the time of sale, however most of the drugs we sell have an expiration date greater than 1 to 2 years

What is your return policy?
Read the refund and cancellation policy

We are unable to accept credit or debit card payments as VISA and Mastercard policies (do not allow pharmacies established outside the US to sell drugs to US customers).
 
How do I place an order?
When you click on an ADD TO CART link, you will be directed to our secure server where you will be registered as our customer. After selecting the required product and its quantity, you will be sent an email with the information of your purchase and the information to make the payment.

What happens once I send my order?
If your payment is received and identified, you will immediately receive an order confirmation email and another email once your order has been shipped.

How do I check the status of my order?
After making your purchase, you will receive an email with your order tracking information. This email contains information about the purchase and a link to the official pages of SEPOMEX, USPS, CANADA POST and PARCEL FORCE.

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We are committed to protecting your privacy with the highest level of security possible. All your personal information, including name and address, is encrypted so that it cannot be read as it is transmitted from your computer to our server. We use the Secure Socket Layer (SSL) protocol which enables end-to-end data protection.

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