Cialis, also known as tadalafil, is a pharmaceutical drug intended to treat various forms of erectile dysfunction (ED) in men. Erectile dysfunction is a condition in which a man has difficulty achieving or maintaining the erection necessary for successful sexual intercourse. Cialis is one of the most well-known and widely used medications for the treatment of ED.
The drug is available in tablet form, which contains the active ingredient tadalafil. It works by increasing blood flow to the sexual organ, which helps in achieving and maintaining an erection. In addition to treating ED, Cialis may also be used in some cases to treat symptoms of benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension.
Cialis: Dosage Details
The standard dosage of Cialis is 20 mg of the active ingredient tadalafil. This dosage is generally recommended for most patients, but a doctor may decide to reduce the dose to 10 mg or increase it to 40 mg, depending on the patient's individual needs and tolerance. Cialis tablets are taken orally, with a drink of water, 30–60 minutes before intended sexual activity.
It is important to follow the doctor's recommendations regarding dosage and frequency of administration to achieve the best results. It is not recommended to exceed the maximum allowable daily dose of tadalafil, which is usually 20 mg.
How does Cialis work?
The mechanism of action of Cialis is that it is a phosphodiesterase type 5 inhibitor and an FDE-5 enzyme that breaks down cyclic guanosine monophosphate (cGMP), a substance that relaxes the smooth muscles of the blood vessels of the sexual organ and increases blood flow to it. By inhibiting FDE-5, Cialis promotes the accumulation of cGMP, which increases the blood supply to the sexual organ and makes it easier to achieve and maintain an erection.
The effect of taking Cialis occurs in the presence of sexual arousal and can last up to 36 hours, making it one of the longest-lasting ED medications.
Contraindications
Contraindications to Cialis play an important role in ensuring the safety and effectiveness of treatment. The main contraindications to the use of Cialis that are important to consider before starting this drug are:
- Hypersensitivity to tadalafil;
- Taking nitrates;
- Use of alpha-adrenoblockers;
- For women and children;
- Renal insufficiency;
- Deformity of the sexual organ;
- Liver dysfunction.
Side effects
Before starting to take this drug, it is important to be aware of possible adverse reactions. Below, we will discuss the main side effects that may occur when using Cialis:
- Headache;
- Heartburn, abdominal discomfort, nausea and rarely vomiting;
- Runny and stuffy nose;
- Skin redness;
- Back and muscle pain;
- Changes in vision;
- Priapism;
- Allergic reactions;
- Increased blood pressure;
- Drowsiness and dizziness.
It is important to note that not all patients experience side effects, and their severity and duration may vary.
Interaction with other medicines
Nitrates: Interactions between Cialis and nitrates such as nitroglycerin or isosorbide dinitrate can cause a dangerous drop in blood pressure. Nitrates are widely used to treat angina pectoris and other cardiovascular diseases. Patients taking nitrates are strictly prohibited from using Cialis. In the event that it is necessary to take Cialis, it is necessary to wait for the complete removal of nitrates from the body.
Alpha-adrenoblockers: Some patients may take alpha-adrenoblockers to treat symptoms of benign prostatic hyperplasia (BPH) or arterial hypertension. Combining alpha-adrenoblockers with Cialis can cause a severe drop in blood pressure. A physician should prescribe and monitor the combination of these drugs.
FDE-5 inhibitors: Cialis is a phosphodiesterase type 5 (PDE-5) inhibitor, as are other medications such as sildenafil (Viagra) and vardenafil (Levitra). Their simultaneous use may lead to increased action and an increased risk of unwanted side effects. Therefore, the concomitant use of different FDE-5 inhibitors is not recommended.
Antihypertensive agents: Cialis may enhance the antihypertensive effect of blood pressure-lowering drugs. Patients taking antihypertensive drugs should consult a physician and monitor blood pressure when using Cialis at the same time.
Antibiotics and antifungals: Some antibiotics (e.g. erythromycin) and antifungals (e.g. ketoconazole) may increase the concentration of tadalafil in the blood, which may increase the risk of side effects. The physician should consider these interactions when prescribing treatment.
Alcohol: Consumption of large amounts of alcohol in combination with Cialis may increase the risk of side effects such as dizziness, drowsiness and changes in blood pressure. It is recommended to avoid excessive alcohol consumption while taking the drug.
Use of Cialis in men and women
The drug Cialis (tadalafil) was originally developed to treat erectile dysfunction in men and is licensed for use in this patient category only. However, there is interest and research regarding its use in women, especially for the treatment of certain medical conditions. Let's take a look at how the use of Cialis may differ between men and women.
In men
Treatment of erectile dysfunction: The main purpose of Cialis is to treat erectile dysfunction in men. The drug helps to improve blood supply to the sexual organ, helping to achieve and maintain an erection in response to sexual stimulation. The effect of Cialis begins 30–60 minutes after taking it and lasts up to 36 hours.
Preventing premature ejaculation: Some studies have shown that Cialis may help some men manage ejaculation by increasing the time to ejaculation. However, this is not the main purpose of the drug and requires more detailed studies.
Female sexual dysfunction
Female sexual dysfunction: Although Cialis does not have official approval for the treatment of female sexual dysfunction, some studies have shown the drug's potential to improve women's sexual satisfaction. However, the results of these studies have not always been conclusive, and their effectiveness among women remains subject to further research.
Treatment of pulmonary hypertension: In some cases, Cialis may be prescribed to women to treat pulmonary hypertension, which is a serious condition. The drug helps to dilate the blood vessels and improve blood circulation in the lungs.
So, Cialis is mainly used by men to treat erectile dysfunction. Its use by women requires more research and an evaluation of the risks and benefits. Women considering treatment options should discuss this with a qualified medical professional.
Duration of action of Cialis
The effects of taking Cialis begin to appear 30–60 minutes after taking it and can last up to 36 hours. This allows patients to have a more flexible approach to sexual activity and not feel an urgent need to take the drug before each sexual act. The half-life of tadalafil is approximately 17.5 hours, which means that half of the drug's dose is eliminated from the body after this period of time.
It should be noted that Cialis is not an aphrodisiac and does not stimulate sexual desire. The effect of the drug is manifested only in the presence of sexual arousal.
Buying Cialis online
Cialis can be purchased online through many online pharmacies. However, you should be careful and choose reliable suppliers before buying. Buy the drug from licensed and reliable online pharmacies. Check the reputation and reviews of the supplier. Be wary of offers of cheap or too-good deals, as this may indicate a fake.
The cost of Cialis can vary depending on the region, pharmacy and the number of pills in the pack. To save money, you can look for promotions, discounts and generic versions of the drug that may be more affordable, but keep in mind that the quality and effectiveness of generics may vary.
Cialis is an effective drug for the treatment of erectile dysfunction in men. It can help many patients regain their sexual performance and improve their quality of life. However, before starting to take Cialis, you should consult a doctor, follow dosage and usage recommendations, and be careful when buying the drug online.
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