DIFFERIN GEL (ADAFERIN IN MEXICO) ADAPALENE 3% 45GR

ADAFERIN ™ is indicated for the topical treatment of acne vulgaris with a predominance of comedones, papules and pustules.

It is especially recommended for facial acne and when the chest and back are affected.

Studies carried out in humans have shown that the topical application of ADAFERIN is effective in reducing inflammatory and non-inflammatory acne lesions (comedones, papules and pustules).

ADAFERIN is a retinoid analogue, which has been shown to have anti-inflammatory properties in both in vivo and in vitro inflammation models; It is stable in the presence of oxygen, light and is not chemically reactive. It binds to specific nuclear receptors for retinoic acid, like tretinoin, but unlike tretinoin, it does not bind to cytosolic receptor binding proteins.

In the rhino mouse model, the comedolytic activity of ADAFERIN was verified, as well as its effects on the abnormal processes of keratinization and epidermal differentiation, both processes being part of the pathogenesis of acne vulgaris.

The mechanism of action of ADAFERIN consists of the normalization of the differentiation of follicular epithelial cells, resulting in a decrease in the formation of microcomedones.

Furthermore, ADAFERIN™ has been proven to be superior to other topical retinoids in standard anti-inflammatory studies, both in vivo and in vitro, inhibiting the chemotactic and chemokinetic responses of human polymorphonuclear leukocytes, as well as the metabolism of inflammatory mediators through lipid acid oxidation. arachidonic.

This profile suggests that the cell-mediated inflammatory component of acne can be modified by the action of ADAFERIN.

The level of absorption of ADAFERIN at the percutaneous level is low; clinical studies have reported that no quantifiable levels were detected in plasma.

The metabolism of ADAFERIN has been identified as a process consisting of O-demethylation, hydroxylation and conjugation.

What are your shipping rates and policies?
At the moment we offer 1 shipping option:

Regular Airmail Delivery (10-12 business days)
 
Once your order has been shipped, we will send you an email to notify you that your product has left our facilities. From this point on, your product is only 15-24 business days.

Please note that orders are shipped on business days only (Monday through Friday, excluding holidays).

You can view our shipping rate and other information after selecting a particular product.

Do you ship internationally?
yes
 
In what currency is my purchase transaction received?
The currency used will be the US dollar.

How will my medication be packaged?
Your order will be properly packaged for your protection in transit to destination.

Where are the medications shipped from?
We ship from our office in Acapulco, Gro. Mexico

Where are the drugs you have to sell made?
Most of the drugs we offer are manufactured in Mexico, some are manufactured in countries such as Germany, England, France and others, all manufactured by large multinational laboratories legally established in Mexico.

What is the expiration date of the medications I receive?
We offer the guarantee that your product will have at least 10 months of use at the time of sale, however most of the drugs we sell have an expiration date greater than 1 to 2 years

What is your return policy?
Read the refund and cancellation policy

We are unable to accept credit or debit card payments as VISA and Mastercard policies (do not allow pharmacies established outside the US to sell drugs to US customers).
 
How do I place an order?
When you click on an ADD TO CART link, you will be directed to our secure server where you will be registered as our customer. After selecting the required product and its quantity, you will be sent an email with the information of your purchase and the information to make the payment.

What happens once I send my order?
If your payment is received and identified, you will immediately receive an order confirmation email and another email once your order has been shipped.

How do I check the status of my order?
After making your purchase, you will receive an email with your order tracking information. This email contains information about the purchase and a link to the official pages of SEPOMEX, USPS, CANADA POST and PARCEL FORCE.

What is your security and privacy policy?
We are committed to protecting your privacy with the highest level of security possible. All your personal information, including name and address, is encrypted so that it cannot be read as it is transmitted from your computer to our server. We use the Secure Socket Layer (SSL) protocol which enables end-to-end data protection.