Levothyroxine, is a synthetic analog of thyroxine, a natural hormone produced by the thyroid gland. It is widely used to treat conditions associated with thyroxine deficiency, such as hypothyroidism and some forms of goiter.
What is Levothyroxine used for?
The answer is to correct hormonal balance in hypothyroidism and other related conditions. The use of Levothyroxine pills involves replenishing the lack of thyroid hormones in the body, which helps to normalize metabolic processes and maintain optimal energy levels.
Side effects and contraindications of Levothyroxine use
Levothyroxine sodica, is a synthetic thyroid hormone substitute used to treat hypothyroidism, a condition in which the thyroid gland does not produce enough hormones. Although Levothyroxine is effective in restoring normal hormone levels, there are certain contraindications and side effects that should be considered before starting therapy.
Contraindications
- Allergy to Levothyroxine or any of the drug's components: Patients with known hypersensitivity should avoid its use.
- Untreated thyrotoxicosis: Use of the drug in patients with active thyrotoxicosis without appropriate treatment may aggravate the symptoms of the disease.
- Acute myocardial insufficiency, acute myocardial infarction, and acute inflammatory thyroid disease: Use of the Levothyroxine pill in these conditions may place an undue strain on the heart.
- Uncontrolled adrenocortical insufficiency: Use of Levothyroxine 100 mcg without prior correction of adrenocortical insufficiency may cause acute adrenocrisis.
Side effects
- Heart palpitations: Palpitations may occur, especially at the beginning of treatment or when switching to a higher dose.
- Anxiety and nervousness: Some patients may experience increased anxiety or nervousness.
- Insomnia: Changes in hormone levels may affect sleep quality.
- Diarrhea or constipation: Metabolic changes may cause changes in the digestive system.
- Osteoporosis: Prolonged use of high doses may contribute to decreased bone density.
- Heart failure: Especially in patients with a history of cardiovascular disease.
- Severe allergic reactions: Including anaphylaxis, angioedema, urticaria, and other severe skin reactions that require immediate medical attention.
- Weight Changes: Weight loss may occur as a result of accelerated metabolism and may be one of the effects of the drug. However, using Levothyroxine for weight loss without a medical indication is wrong and dangerous.
In addition, there is a risk of developing myopathy, a condition in which muscle fibers do not function properly, which can manifest as muscle weakness or pain. In rare cases, there may be signs of hyperthyroidism due to an excess of the hormone, especially if the dosage exceeds the body's individual needs. Symptoms include weight loss, rapid heartbeat, sweating and nervousness.
Dosage
Levothyroxine sodica dosage, is a critical aspect of the treatment of hypothyroidism and other conditions associated with thyroid hormone deficiency. The proper dosage of this medication requires careful consideration based on the patient's individual needs, medical history, age, weight, and overall health.
- Adults with hypothyroidism: For adults without cardiovascular disease, the starting dose may be 50 to 100 mcg per day, with subsequent adjustments based on clinical response and TTG (thyroid hormone) levels.
- Elderly patients and patients with cardiovascular disease: The starting dose is usually lower, about 25–50 mcg per day, with cautious dose increases to minimize the risk of complications.
- Children: Dosage for children is individualized, usually based on weight and age, and requires careful medical supervision.
- Dose Adjustment: Levothyroxine dosage is adjusted based on the patient's TSH levels and clinical condition. Periodic TTG testing is recommended every 6–8 weeks after treatment initiation or dose modification to ensure dosage adequacy. If necessary, the dose may be increased by approximately 25 mcg per day every 4–6 weeks until the desired TTH level is achieved.
- Pregnancy: Women with hypothyroidism who are pregnant or planning a pregnancy may need to increase the dose of the drug because the need for thyroid hormones increases during pregnancy.
- Thyroid cancer: Patients being treated for thyroid cancer may require high doses of Levothyroxine to keep their TSH levels low or even undetectable as part of their antiretroviral therapy.
Levothyroxine pills should be taken on an empty stomach, 30–60 minutes before meals, to maximize its absorption. Interactions with certain foods and supplements, such as calcium and iron, may decrease the absorption of the drug. Consistency of drug administration is important to maintain stable hormone levels in the blood.
Whether 100 mcg of Levothyroxine is a high dose depends on the patient's individual needs and TTG levels. Levothyroxine 100 mcg is a standard dose that can be adjusted depending on the body's response and laboratory values.
Levothyroxine prices may vary depending on the manufacturer, dosage and country of purchase. Today, it is possible to buy Levothyroxine tablets online, but this should be done only in reliable pharmacies and with a doctor's prescription.
Duration of the therapeutic effect of Levothyroxine
Levothyroxine usually acts within 24 hours, so it is taken daily. Impaired liver or kidney function may slow the metabolism and excretion of Levothyroxine, requiring dose adjustment. Slower metabolism and excretion of levothyroxine may be observed in elderly patients, which may also require dose adjustment.
Levothyroxine administered to the body goes through several steps of metabolism and excretion before it is completely eliminated. After ingestion, Levothyroxine is absorbed primarily in the small intestine. Maximum blood concentrations are reached approximately 5–6 hours after ingestion. Binding to plasma proteins such as thyroxine-binding globulin (TSG), albumin and predalbumin is more than 99%, which ensures prolonged circulation of the hormone in the blood.
The drug is metabolized in the liver, kidneys, and other tissues where it is deiodinated to triiodothyronine (T3), which is the more active form of thyroid hormone, and to reverse T3, which is metabolically inactive. This process helps regulate hormone levels and provides for the body's T3 needs.
Levothyroxine metabolites are excreted from the body through the kidneys and with bile through the intestines. Small amounts of unchanged Levothyroxine may also be excreted with urine and feces. The half-life of the drug from the body is approximately 7 days for healthy individuals, but may be longer in patients with hypothyroidism and shorter in patients with hyperthyroidism.
To summarize, Levothyroxine Sodica is a vital medication for many people suffering from thyroid disease. Proper use, accurate adherence to dosage recommendations, and regular medical monitoring can result in significant improvements in patients' quality of life.
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Most of the drugs we offer are manufactured in Mexico, some are manufactured in countries such as Germany, England, France and others, all manufactured by large multinational laboratories legally established in Mexico.
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