What is caridoxen?
Naproxen is a non-steroidal anti-inflammatory with analgesic and anti-inflammatory action.
Non-steroidal anti-inflammatory drugs (NSAIDs) such as Naproxen selectively inhibit the synthesis of activators (prostaglandins), which are the most important mediators of inflammation. Through their inhibitory action on cyclooxygenase and its COX 1 and COX 2 isoenzymes. NSAIDs work by preventing prostaglandin synthesis by inhibiting COX enzymatic activity at sites of inflammation and in the CNS. If inhibition of prostaglandin (PGE2 and Pl2) production is achieved, the signaling pathways are not activated and effectively reduce the increase in pain sensitization that accompanies prostaglandin activity. Naproxen affects pain receptors in the spinal cord and in major centers of the Central Nervous System and produces pain attenuation by activation of spinal cord substance P and glutamate receptors. The effects of naproxen on voltage-gated Na+, Ca+, and K+ channels, transient potential receptors, and IC channels have been documented.
Carisoprodol is a muscle relaxant developed from meprobamate, it has a fast effect and lasts 4 to 6 hours.
Naproxen inhibits prostaglandin synthesis like other similar agents.
Carisoprodol is a centrally acting muscle relaxant that indirectly relaxes skeletal muscles. The carisoprodol metabolite, meprobamate, has anxiolytic and sedative properties.
Naproxen is rapidly and completely absorbed from the gastrointestinal tract after oral administration. Concomitant administration with food may delay its absorption, but does not alter its effect. Peak plasma levels after a dose are reached in 2 to 4 hours, depending on food intake.
The pharmacokinetics of carisoprodol and its metabolite meprobamate were studied in a study of 24 healthy subjects (12 men and 12 women) who received single doses of 350 mg carisoprodol. The meprobamate Cmax after administration of a single 350-mg dose of carisoprodol was 2.46 mcg/mL (median ± SD), which is approximately 25% of the meprobamate Cmax (approximately 8 mcg/mL) after administration of a single 400 mg dose of meprobamate.
The absolute bioavailability of carisoprodol has not been determined. Following administration of a single 350 mg dose of carisoprodol, the mean time to reach plasma concentrations (Tmax) of carisoprodol was approximately 1.5 to 2 hours. Co-administration of a high-fat meal with 350 mg carisoprodol had no effect on the pharmacokinetics of carisoprodol.
Caridoxen 250mg
Naproxen has a volume of distribution of 0.16 l/kg. It is more than 99% bound to plasma proteins at normal therapeutic doses. At doses greater than 500 mg/day there is no direct relationship between dose and plasma concentration due to increased clearance caused by saturation of its binding to plasma proteins at high doses. However, the concentration of non-protein bound naproxen continues to increase in a dose proportional manner. Stable plasma levels of naproxen are reached after 3 to 4 days. Naproxen penetrates synovial fluid, crosses the placenta, and is present in breast milk at approximately 1% of the maternal plasma concentration.
Naproxen is extensively metabolized in the liver to 6-o-desmethyl-naproxen. The main route of metabolism of carisoprodol is through the liver by the enzyme cytochrome CYP2C19 to form meprobamate. This enzyme shows a genetic polymorphism.
Approximately 95% of naproxen is excreted in the urine, primarily as naproxen (less than 1%), 6-o-desmethyl-naproxen (less than 1%) or their conjugates (66 to 92%). The rate of excretion has been found to closely match the rate at which the drug disappears from the plasma. In smaller amounts, less than 3% is excreted in the feces. Naproxen clearance is approximately 0.13 mL/min/kg. The elimination half-life of naproxen is approximately 14 hours and is independent of clinical form or formulation. Carisoprodol is eliminated by both renal and non-renal routes with a terminal elimination half-life of approximately 2 hours after administration of a single 350 mg carisoprodol dose. The half-life of meprobamate is approximately 10 hours after administration of a single dose of 350 mg carisoprodol.
ACTIVE INGREDIENT
CARISOPRODOL/NAPROXEN 250/200MG 30CAPS
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At the moment we offer 1 shipping option:
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yes
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Most of the drugs we offer are manufactured in Mexico, some are manufactured in countries such as Germany, England, France and others, all manufactured by large multinational laboratories legally established in Mexico.
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We offer the guarantee that your product will have at least 10 months of use at the time of sale, however most of the drugs we sell have an expiration date greater than 1 to 2 years
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