DALACIN T® is indicated as an auxiliary in the treatment of acne vulgaris.
Pharmacokinetic Properties:
Following multiple topical applications of clindamycin phosphate at a concentration equivalent to 10 mg clindamycin per mL in a solution of water and isopropyl alcohol, very low levels of clindamycin are present in the serum (0-3 ng/mL) and less than 0.2% of the dose is recovered in the urine as clindamycin.
Clindamycin activity has been demonstrated on comedones in patients with acne. The average concentration of antibiotic activity in comedones extracted after application of topical clindamycin solution for 4 weeks was 597 mcg/g of comedonal material (range 0-1490). Clindamycin in vitro inhibits all Propionibacterium acnes cultures tested (MIC of 0.4 mcg/ml). Free fatty acids on the skin surface decrease by approximately 14 to 2% after application of clindamycin.
Geriatric Use: Clinical studies of topical clindamycin did not include sufficient numbers of subjects aged 65 years and older to determine whether they responded differently than younger subjects.
Pharmacodynamic Properties:
Mechanism of action:
Clindamycin is an antibiotic from the lincosamide group that inhibits bacterial protein synthesis. It binds to the 50S ribosomal subunit and affects both ribosome assembly and the translation process. Although clindamycin phosphate is inactive in vitro, rapid hydrolysis in vivo converts this compound to antibacterially active clindamycin.
Clindamycin has been shown to have in vitro activity against isolates of the following organisms;
Anaerobic, non-spore-forming gram-positive bacilli, including:
Propionibacterium acnes.
Pharmacodynamic effects:
Efficacy is related to the period of time in which the level of the agent is above the minimum inhibitory concentration (MIC) of the pathogen (% T/MIC).
Endurance:
Clindamycin resistance in Propionibacterium acnes can be caused by mutations in the antibiotic binding site rRNA or by methylation of specific nucleotides in the 23S RNA of the 50S ribosomal subunit. These alterations can determine cross resistance to macrolides and streptogramins B (MLSB phenotype). Macrolide-resistant isolates should be tested for inducible clindamycin resistance using the D-test. Cross resistance has been demonstrated between clindamycin and lincomycin.
The prevalence of acquired resistance may vary geographically and over time for selected species, and local information on resistance is desirable, especially when treating severe infections. As necessary, expert advice should be sought when the local prevalence of resistance is such that the usefulness of the agent in at least some types of infections is questionable. Particularly in severe infections or therapy failure, microbiological diagnosis with verification of the pathogen and its susceptibility to clindamycin is recommended.
BRAND NAME
CLEOCIN T (DALACIN T IN MEXICO)
ACTIVE INGREDIENT
CLINDAMYCIN 1%
What are your shipping rates and policies?
At the moment we offer 1 shipping option:
Regular Airmail Delivery (15-24 business days)
Once your order has been shipped, we will send you an email to notify you that your product has left our facilities. From this point on, your product is only 15-24 business days.
Please note that orders are shipped on business days only (Monday through Friday, excluding holidays).
You can view our shipping rate and other information after selecting a particular product.
Do you ship internationally?
yes
In what currency is my purchase transaction received?
The currency used will be the US dollar.
How will my medication be packaged?
Your order will be properly packaged for your protection in transit to destination.
Where are the medications shipped from?
We ship from our office in Acapulco, Gro. Mexico
Where are the drugs you have to sell made?
Most of the drugs we offer are manufactured in Mexico, some are manufactured in countries such as Germany, England, France and others, all manufactured by large multinational laboratories legally established in Mexico.
What is the expiration date of the medications I receive?
We offer the guarantee that your product will have at least 10 months of use at the time of sale, however most of the drugs we sell have an expiration date greater than 1 to 2 years
What is your return policy?
Read the refund and cancellation policy
We are unable to accept credit or debit card payments as VISA and Mastercard policies (do not allow pharmacies established outside the US to sell drugs to US customers).
How do I place an order?
When you click on an ADD TO CART link, you will be directed to our secure server where you will be registered as our customer. After selecting the required product and its quantity, you will be sent an email with the information of your purchase and the information to make the payment.
What happens once I send my order?
If your payment is received and identified, you will immediately receive an order confirmation email and another email once your order has been shipped.
How do I check the status of my order?
After making your purchase, you will receive an email with your order tracking information. This email contains information about the purchase and a link to the official pages of SEPOMEX, USPS, CANADA POST and PARCEL FORCE.
What is your security and privacy policy?
We are committed to protecting your privacy with the highest level of security possible. All your personal information, including name and address, is encrypted so that it cannot be read as it is transmitted from your computer to our server. We use the Secure Socket Layer (SSL) protocol which enables end-to-end data protection.
