Clonazepam, belonging to the benzodiazepine class, exhibits a range of effects including anticonvulsant, sedative, muscle relaxant, and anxiolytic properties. These effects are thought to be primarily mediated by GABA-related inhibition in postsynaptic activity, while select animal studies also suggest an impact on serotonin pathways.
Studies in both animals and electroencephalographic evaluations in humans reveal that clonazepam has a rapid suppressive effect on various forms of paroxysmal activity. This includes conditions like absence seizures (petit mal), slow spike waves, generalized spikes, and spikes occurring in different locations, in addition to irregular waves and spikes.
While clonazepam effectively suppresses generalized EEG abnormalities, its benefits extend to focal epilepsies as well. The absorption of clonazepam from the gastrointestinal tract is efficient. In adults administered a 2 mg oral dose of micronized clonazepam, peak blood concentrations of 6.5-13.5 ng/mL were observed 1 to 2 hours after ingestion. However, in some individuals, maximum concentration occurs between 4 to 8 hours. Therapeutic effects in plasma concentrations are believed to lie between 20-80 ng/ml.
Sustained therapeutic levels can be achieved in adults with a daily dosage of clonazepam divided into three doses, while children aged 6 to 13 years are recommended 1.5-4 mg daily in three doses. The onset of action is typically within 20 to 60 minutes, lasting 6 to 8 hours in younger individuals and exceeding 12 hours in adults.
The distribution of clonazepam is analogous to other benzodiazepines, although there is limited information available. It is known to cross the blood-brain barrier and placenta. Clonazepam undergoes hepatic metabolism to generate several metabolites, including 7-aminoclonazepam, 7-acetaminoclonazepam, 3-hydroxy derivatives, and the parent compound. These metabolites are excreted mainly in urine, along with their conjugates.
In conclusion, clonazepam's distinct pharmacological properties make it a valuable member of the benzodiazepine family, contributing to the treatment of various conditions.
What are your shipping rates and policies?
At the moment we offer 1 shipping option:
Regular Airmail Delivery (15-24 business days)
Once your order has been shipped, we will send you an email to notify you that your product has left our facilities. From this point on, your product is only 15-24 business days.
Please note that orders are shipped on business days only (Monday through Friday, excluding holidays).
You can view our shipping rate and other information after selecting a particular product.
Do you ship internationally?
In what currency is my purchase transaction received?
The currency used will be the US dollar.
How will my medication be packaged?
Your order will be properly packaged for your protection in transit to destination.
Where are the medications shipped from?
We ship from our office in Acapulco, Gro. Mexico
Where are the drugs you have to sell made?
Most of the drugs we offer are manufactured in Mexico, some are manufactured in countries such as Germany, England, France and others, all manufactured by large multinational laboratories legally established in Mexico.
What is the expiration date of the medications I receive?
We offer the guarantee that your product will have at least 10 months of use at the time of sale, however most of the drugs we sell have an expiration date greater than 1 to 2 years
What is your return policy?
Read the refund and cancellation policy
We are unable to accept credit or debit card payments as VISA and Mastercard policies (do not allow pharmacies established outside the US to sell drugs to US customers).
How do I place an order?
When you click on an ADD TO CART link, you will be directed to our secure server where you will be registered as our customer. After selecting the required product and its quantity, you will be sent an email with the information of your purchase and the information to make the payment.
What happens once I send my order?
If your payment is received and identified, you will immediately receive an order confirmation email and another email once your order has been shipped.
How do I check the status of my order?
After making your purchase, you will receive an email with your order tracking information. This email contains information about the purchase and a link to the official pages of SEPOMEX, USPS, CANADA POST and PARCEL FORCE.
We are committed to protecting your privacy with the highest level of security possible. All your personal information, including name and address, is encrypted so that it cannot be read as it is transmitted from your computer to our server. We use the Secure Socket Layer (SSL) protocol which enables end-to-end data protection.