Recent advances in pharmacological concepts allow us to mention more useful and complete aspects for understanding the clinical management of benzodiazepines and their therapeutic actions.
The pharmacological actions of benzodiazepines depend on the activation of 2 specific receptors. The central benzodiazepine receptor, present in various areas of the Central Nervous System (CNS), which is a component of the more complex structure that comprises receptors called GABA-A (gamma-aminobutyric acid), stimulation of these structures increases neurotransmission GABAergic, with intense inhibitory and neuroendocrine effects, and the peripheral benzodiazepine receptor, functionally and structurally different from the GABA-A receptor, which has been found in peripheral tissues, and even in the CNS, in some neurons, glial cells, and the pituitary gland. .
Physiologically, benzodiazepine receptors bind to a natural family of natural peptides called endozepines, which modulate various biological activities, either central or peripheral; synthetic molecules such as benzodiazepines mimic (at least partially) the effects of these peptides. Benzodiazepines, especially Alprazolam, have a clear inhibitory influence on the activity of the adrenal-hypothalamic-pituitary axis, effects that appear to be mediated through the hypothalamic and suprahypothalamic pathways.
The intense inhibitory influence of Alprazolam on these neurological pathways explains its particular efficacy in the treatment of clinical entities such as depression and panic. In a simplified way, one can understand the therapeutic effects of Alprazolam considering its ability to depress or decrease the functions of the CNS, with a directly proportional relationship of dose-effect, obtaining everything from lysis of anxiety and sedation to deep hypnosis.
Alprazolam administered orally is rapidly absorbed, finding maximum plasmatic levels between the first and second hours after ingestion. Its bioavailability is 94%. Some high-fat foods two hours before the Alprazolam dose can increase its absorption. It is 80% protein bound and its volume of distribution differs significantly in young and elderly men, but not in women of different ages. The volume of distribution is greater in obese subjects compared to control subjects.
Alprazolam metabolism is carried out mainly in the liver via hydroxylation catalyzed by cytochrome P450, it produces 4 metabolites; alpha-hydroxyAlprazolam, which has a minimal activity of approximately half that of Alprazolam, although it does not contribute to its pharmacological effects, benzophenone, an inactive metabolite, desmethyl Alprazolam and 4-hydroxyAlprazolam which has less than a quarter of the activity Alprazolam, although it does not contribute to its pharmacological effects either. The elimination half-life of Alprazolam is 12 to 15 hours. It presents a renal elimination in 80%, which decreases in the elderly.
LABORATORY
PISA FARMACEUTICA
ACTIVE INGREDIENT
ALPRAZOLAM 0.50MG
What are your shipping rates and policies?
At the moment we offer 1 shipping option:
Regular Airmail Delivery (10-12 business days)
Once your order has been shipped, we will send you an email to notify you that your product has left our facilities. From this point on, your product is only 15-24 business days.
Please note that orders are shipped on business days only (Monday through Friday, excluding holidays).
You can view our shipping rate and other information after selecting a particular product.
Do you ship internationally?
yes
In what currency is my purchase transaction received?
The currency used will be the US dollar.
How will my medication be packaged?
Your order will be properly packaged for your protection in transit to destination.
Where are the medications shipped from?
We ship from our office in Acapulco, Gro. Mexico
Where are the drugs you have to sell made?
Most of the drugs we offer are manufactured in Mexico, some are manufactured in countries such as Germany, England, France and others, all manufactured by large multinational laboratories legally established in Mexico.
What is the expiration date of the medications I receive?
We offer the guarantee that your product will have at least 10 months of use at the time of sale, however most of the drugs we sell have an expiration date greater than 1 to 2 years
What is your return policy?
Read the refund and cancellation policy
We are unable to accept credit or debit card payments as VISA and Mastercard policies (do not allow pharmacies established outside the US to sell drugs to US customers).
How do I place an order?
When you click on an ADD TO CART link, you will be directed to our secure server where you will be registered as our customer. After selecting the required product and its quantity, you will be sent an email with the information of your purchase and the information to make the payment.
What happens once I send my order?
If your payment is received and identified, you will immediately receive an order confirmation email and another email once your order has been shipped.
How do I check the status of my order?
After making your purchase, you will receive an email with your order tracking information. This email contains information about the purchase and a link to the official pages of SEPOMEX, USPS, CANADA POST and PARCEL FORCE.
What is your security and privacy policy?
We are committed to protecting your privacy with the highest level of security possible. All your personal information, including name and address, is encrypted so that it cannot be read as it is transmitted from your computer to our server. We use the Secure Socket Layer (SSL) protocol which enables end-to-end data protection.
