SINPEBAC® is indicated for skin infections such as impetigo, ecthyma, folliculitis, furunculosis, diaper dermatitis due to Candida albicans and/or Staphylococcus aureus. Also in infections of surgical or traumatic wounds, abrasions, ulcers, burns and other skin conditions such as infected psoriasis and atopic dermatitis. When applied to the skin surrounding cannulas and catheters, it prevents their colonization by Staphylococcus aureus and other pathogens sensitive to mupirocin.
Mupirocin is the first topical antibiotic with no structural relationship to other known antibiotics. It has been shown in studies with Staphylococcus aureus and Escherichia coli that SINPEBAC® binds to isoleucyl-RNAt synthetase, competing with isoleucine for the binding site to the enzyme; consequently inhibiting the synthesis of proteins and RNA of the bacteria.
The inhibitory action of SINPEBAC® 2% applied topically results in a bactericidal effect, mainly on the normal acidic pH of the skin.
The spectrum of SINPEBAC® mainly includes Gram-positive aerobic bacteria that cause skin infections, including Staphylococcus aureus, Staphylococcus epidermidis and S. saprophyticus, whether or not they produce penicillinases. At normal skin pH (5.5), the minimum inhibitory concentration of SINPEBAC® on S. aureus is 0.016 mg/mL. SINPEBAC® is active against S. aureus resistant to other antibiotics, including penicillin, aminoglycosides, erythromycin, chloramphenicol and tetracycline. Cross resistance of SINPEBAC® with other antibiotics has not been demonstrated.
Other Gram positive bacteria sensitive to SINPEBAC® are: Streptococcus pneumoniae, Streptococcus pyogenes, S. agalactie and S. viridans; the minimum inhibitory concentration required is 0.12-2 mg/mL.
It is also active against some Gram-negative bacteria such as Haemophilus influenzae, N. catarrhalis, N. Gonorrhoeae, N. meningitidis, Bordetella pertussis, Pasteurella multocida, in which the minimum inhibitory concentration is 0.12-0.2 mg/mL.
Clinical studies in bacterial skin infections have shown a clinical cure of 85% to 100% (average 94%) and a bacteriological eradication of 94% to 100% (average 97%).
In an in vitro study on infected tissue, SINPEBAC® was shown to eliminate bacteria rapidly. One hour after treatment, 29% of S. aureus and 46% of S. epidermidis survived; After 24 hours, only 0.35% of the bacteria were present.
It has been reported in some studies that SINPEBAC® eliminates Candida albicans at minimum inhibitory concentrations of 512 mg/mL, in a period of 2-6 days of treatment.
The antifungal action of mupirocin is related to the introduction of the drug into the yeast cell by a high-affinity transport system mediated by amino acids.
In a study in healthy adults with radiolabeled mupirocin applied to intact skin, no systemic absorption was detected and 2-4% of the radioactivity was located in the stratum corneum of the epidermis. Application to diseased or traumatized skin may result in penetration into deeper layers of skin. There is evidence that some enzymes present in the skin can metabolize mupirocin to 3% monic acid. Mupirocin has been reported to remain active for at least 24 hours after application to the skin.
ACTIVE INGREDIENT
MUPIROCIN 2%
CONTAINT
1 TUBE OINTMENT 15GR
What are your shipping rates and policies?
At the moment we offer 1 shipping option:
Regular Airmail Delivery (10-12 business days)
Once your order has been shipped, we will send you an email to notify you that your product has left our facilities. From this point on, your product is only 15-24 business days.
Please note that orders are shipped on business days only (Monday through Friday, excluding holidays).
You can view our shipping rate and other information after selecting a particular product.
Do you ship internationally?
yes
In what currency is my purchase transaction received?
The currency used will be the US dollar.
How will my medication be packaged?
Your order will be properly packaged for your protection in transit to destination.
Where are the medications shipped from?
We ship from our office in Acapulco, Gro. Mexico
Where are the drugs you have to sell made?
Most of the drugs we offer are manufactured in Mexico, some are manufactured in countries such as Germany, England, France and others, all manufactured by large multinational laboratories legally established in Mexico.
What is the expiration date of the medications I receive?
We offer the guarantee that your product will have at least 10 months of use at the time of sale, however most of the drugs we sell have an expiration date greater than 1 to 2 years
What is your return policy?
Read the refund and cancellation policy
We are unable to accept credit or debit card payments as VISA and Mastercard policies (do not allow pharmacies established outside the US to sell drugs to US customers).
How do I place an order?
When you click on an ADD TO CART link, you will be directed to our secure server where you will be registered as our customer. After selecting the required product and its quantity, you will be sent an email with the information of your purchase and the information to make the payment.
What happens once I send my order?
If your payment is received and identified, you will immediately receive an order confirmation email and another email once your order has been shipped.
How do I check the status of my order?
After making your purchase, you will receive an email with your order tracking information. This email contains information about the purchase and a link to the official pages of SEPOMEX, USPS, CANADA POST and PARCEL FORCE.
What is your security and privacy policy?
We are committed to protecting your privacy with the highest level of security possible. All your personal information, including name and address, is encrypted so that it cannot be read as it is transmitted from your computer to our server. We use the Secure Socket Layer (SSL) protocol which enables end-to-end data protection.
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